Team Introduction


Frances Brook, PhD
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford

Dr Brook completed a D.Phil at Oxford in the Department of Agricultural Sciences, studying ovarian structure and function in the wood mouse, Apodemus sylvaticus. Following a post-doctoral position at Washington University in St. Louis she returned to Oxford to work on post-implantation mouse embryo development with Dr Andrew Copp. Subsequently she joined the laboratory of Professor Sir Richard Gardner to study the biology of mouse embryonic stem cells, work that involved the derivation of numerous new ES cell lines. She then moved to the Nuffield Department of Obstetrics & Gynaecology to work in the laboratory of Professor Helen Mardon where she derived several human embryonic stem cell lines. Currently she is in the Radcliffe Department of Medicine, Division of Cardiovascular Medicine, in Dr Matt Daniel’s group, working on a project to derive induced pluripotent stem cells (iPSC) from patients who carry mutations that result in cardiomyopathies. The iPSC are differentiated into cardiomyocytes that can be used to study the effects of drug treatment upon the disease phenotype.