(2021/12/03 更新)

昱星生物科技持續創新，研發的腳步始終沒有停過。2021 年我們陸續有幾項新的研究成果，敬請期待我們的新產品上線！

1. Grieve AG, Yeh Y-C, Chang YF, Huang H-Y, Zarcone L, Breuning J, Johnson N, Stříšovský K, Brown MH, Parekh AB, Freeman M. Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation. Molecular Cell. 2021 Dec 2;81(23):4784-4798.e7.
2. Yang D-M, Chang YF Versatile Cell and Animal Models for Advanced Investigation of Lead Poisoning. Biosensors (Basel). 2021 Oct 4;11(10):371.
3. Qian Y, Cosio DMO, Piatkevich KD, Aufmkolk S, Su W-C, Celiker OT, Schohl A, Murdock MH, Aggarwal A, Chang YF, Wiseman PW, Ruthazer ES, Boyden ES, Campbell RE. Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging. PLOS Biology. 2020;18(11):e3000965.
4. Zarowny L, Aggarwal A, Rutten VMS, Kolb I, Patel R, Huang H-Y, Chang YF, Phan T, Kanyo R, Ahrens MB, Allison WT, Podgorski K, Campbell RE. Bright and High-Performance Genetically Encoded Ca²⁺ Indicator Based on mNeonGreen Fluorescent Protein. ACS Sensors. 2020;5(7):1959-68.
5. Yang D-M, Fu T-F, Lin C-S, Chiu T-Y, Huang C-C, Huang H-Y, Chung M-W, Lin Y-S, Manurung RV, Nguyen PNN, Chang YF. High-performance FRET biosensors for single-cell and in vivo lead detection. Biosensors and Bioelectronics. 2020;168:112571.
6. Shen Y, Dana H, Abdelfattah AS, Patel R, Shea J, Molina RS, Rawal B, Rancic V, Chang YF, Wu L, Chen Y, Qian Y, Wiens MD, Hambleton N, Ballanyi K, Hughes TE, Drobizhev M, Kim DS, Koyama M, Schreiter ER, Campbell RE. A genetically encoded Ca²⁺ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578. BMC Biology. 2018;16(1):9.
7. Chang YF, Broyles CN, Brook FA, Davies MJ, Turtle CW, Nagai T, Daniels MJ. Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics. PLOS ONE. 2017;12(4):e0174181.
8. Wu J, Liu L, Matsuda T, Zhao Y, Rebane A, Drobizhev M, Chang YF, Araki S, Arai Y, March K, Hughes TE, Sagou K, Miyata T, Nagai T, Li W-h, Campbell RE. Improved Orange and Red Ca²⁺ Indicators and Photophysical Considerations for Optogenetic Applications. ACS Chemical Neuroscience. 2013;4(6):963-72.
9. Saito K, Chang YF, Horikawa K, Hatsugai N, Higuchi Y, Hashida M, Yoshida Y, Matsuda T, Arai Y, Nagai T. Luminescent proteins for high-speed single-cell and whole-body imaging. Nature communications. 2012;3(1):1262.
10. Chang YF, Arai Y, Nagai T. Optogenetic activation during detector “dead time” enables compatible real-time fluorescence imaging. Neuroscience Research. 2012;73(4):341-7.
11. Zhao Y, Araki S, Wu J, Teramoto T, Chang YF, Nakano M, Abdelfattah AS, Fujiwara M, Ishihara T, Nagai T, Campbell RE. An Expanded Palette of Genetically Encoded Ca²⁺ Indicators. Science. 2011;333(6051):1888-91.